Fasting and Fasting Mimicking Diet for treatment of autoimmune diseases | Valter Longo

[Rhonda]: The shrinking of the organs and
then sort of in the refeeding phase the re-growing, is kind of something I wanted to talk to you
about as well, this rejuvenation process, because you’ve obviously shown this now in
several different studies both with fasting and fasting-mimicking diet in animals, where
they lose a significant amount of their different organs, right? And I think that you…maybe you want to talk
about this, the…what… [Valter]: Yes. So in mice for example, if you look at the
weight of most organs, and this of course was known for calorie restriction long term. But with fasting, and fasting-mimicking diet,
this happens much more rapidly. So the organs will be smaller, and at the
end of the days of fasting-mimicking diet, and then you refeed and of course they go
back to the normal level, right? So there is really, there is this shrinking
and re-expanding effect. Now, we don’t know how much of it is cells
becoming smaller, versus cells being killed, but clearly there is killing of cells. And certainly of course we are also very interested
in, is there preferential killing of the damaged cells? And we’ve started to show that in our multiple
sclerosis mouse model, and also the human study, there was evidence that the white blood
cell level temporarily was reduced during the, at the end of the fasting cycles and
then went back to normal. So yeah, so we suspect that there are these
fasting-dependent, depletion of both intracellular components, you know, autophagy, and cellular
components, and then we’ve shown the stem cell to be activated, and then the stem cell
during the refeeding part. And that’s another very important point, is
that differentiates it to most of other interventions, right? All of a sudden…even the intermittent fasting. Because you don’t have enough time. If you do like even one day, it barely even
gets you into the ketogenic mode, right? And of course if you do it for one day, you
wouldn’t want to break down too many of the components. That’s probably…having all the glycogen
and having all the digestion takes 30 hours to complete the food digestion, from the time
you eat to the time that all the calories have been taken up, it takes probably over
a day. So that’s a very important distinction between
the prolonged fasting and everything else, including calorie restriction, which does
not have the refeeding moment, right? So, if the rebuilding happens during refeeding
and you never have it, then of course you’re missing out the reconstruction part, which
is as important as the destruction part.

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